The journal welcomes all kind of research/review/abstract papers regarding Health Professions (miscellaneous), Emergency Medical Services, Emergency Medicine, Public Health, Environmental and Occupational Health and so on. Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Latest Journal Published Here MK-20-04-2025-2112 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Tele-Medical Technologies Usage In Medical Treatment Organizations Of Federal Medical And Biological Agency The main issues of provision of medical help and treatment with usage of tele-medical technologies (TMT) were considered, including victims in emergency situations (ES), in medical treatment organizations (MTO) of Federal Medical and Biological Agency (FMBA of Russia). Noticed that an experience of conducting of tele-medical consultations (TMC) which was made in All-Russian Center of Disaster Medicine “Zashchita” (was handed over to FMBA of Russia in 2020) allowed to increase number of MTO of FMBA of Russia which are participated in conducting of medical consultation by the sche Learn More MK-08-01-2025-2112 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Integrating Virtual Reality and Artificial intelligence Tools to Optimize Interprofessional Coordination in Clinical Care Interprofessional coordination breakdowns contribute substantially to adverse events in clinical care, with up to 10% of hospital patients affected and millions of associated deaths worldwide. Emerging technologies—artificial intelligence (AI) and virtual reality (VR)—offer synergistic opportunities to enhance team communication, decision making, and workflow efficiency, yet their combined impact on multidisciplinary coordination has not been systematically evaluated... Learn More MK-07-01-2025-2112 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Evaluating Infection‐Control Practice Among Surgical, Anesthesia, and Radiology Teams Healthcare‐associated infections (HAIs) in perioperative and imaging settings pose substantial risks to patient safety. Anesthesia and imaging technologists are pivotal in infection prevention but often exhibit suboptimal compliance with protocols. This systematic review aimed to synthesize global and Saudi Arabian evidence on technologist adherence to infection‐control measures, identify effective interventions, and inform targeted strategies for improvement.. Learn More MK-25-01-2025-2113 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Anesthesia Equipment-Related Errors in the Operating Room: Incidence Rate and Management Methods Equipment-related errors in the operating room (OR) are a common source of perioperative disruption, posing significant threats to patient safety, surgical efficiency, and healthcare resources. These errors, ranging from device malfunctions to setup failures, are often preventable and underreported. This systematic review.. Learn More MK-08-03-2025-2146 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Prediction Model for Obesity in Women of Reproductive Age in Deli Serdang, Indonesia Obesity is an excessive accumulation of body fat that can lead to health problems. It is characterized by an energy imbalance, where a positive energy balance is ultimately stored as fat in body tissues. Several factors influence obesity, especially in women of reproductive age, including predisposing, reinforcing, and enabling factors. To determine the factors for the obesity prediction model in women of reproductive age in Deli Serdang, Indonesia. This study is an analytical observational study with a cross-sectional design. A total of 290 samples were selected using purposive sampling. Dat Learn More Effectiveness of National Reporting Systems in Capturing Adverse Drug Events Across Healthcare Cadres Adverse drug events (ADEs) are a leading cause of preventable patient harm worldwide. National pharmacovigilance systems play a critical role in detecting and mitigating ADEs; however, their effectiveness varies, especially in capturing reports from all healthcare professionals including nurses, physicians, and pharmacists. This systematic review followed PRISMA 2020 guidelines. Learn More MK-08-03-2025-2146 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Laboratory Biomarkers Predictive of Respiratory Failure in Hospitalized Patients: A Systematic Review Respiratory failure is a leading cause of mortality among hospitalized patients, especially during infectious outbreaks such as COVID-19. Early identification of patients at risk is essential to improving outcomes and optimizing resource allocation. Laboratory biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), D-dimer, and neutrophil-to-lymphocyte ratio (NLR) have shown promise in predicting respiratory deterioration, but .. Learn More Medicina Katastrof(ISSN:2070-1004) (E-ISSN:2686-7966) Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) is a monthly peer-reviewed scopus-indexed journal from 2019 to 2024. The publisher of this journal is A.I. Burnazyan Federal Medical Biophysical Center. Medicina Katastrof committed to gathering and disseminating excellent research achievements. The journal welcomes all kind of research/review/abstract papers regarding Health Professions (miscellaneous), Emergency Medical Services, Emergency Medicine, Public Health, Environmental and Occupational Health and so on. MK-20-01-2025-2112 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Effectiveness of Continuing Professional Development (CPD) Programs for Health Professionals Continuing Professional Development (CPD) programs are essential in maintaining and improving healthcare professionals’ competencies, ensuring quality patient care and safety. Given the global emphasis on lifelong learning in healthcare, evaluating the effectiveness of CPD interventions is crucial for policy development and practice improvement. This systematic review aims to assess the effectiveness of CPD programs across various health professions and settings, including outcomes related to clinical performance, knowledge acquisition, and barriers to implementation. Learn More MK-20-01-2025-2112 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Antimicrobial‑Resistance Patterns in Tertiary Hospitals in the Gulf Region: A Systematic Review Antimicrobial resistance (AMR) presents a critical threat to healthcare systems globally, with tertiary hospitals serving as high-risk hubs for the emergence and spread of resistant pathogens. In the Gulf Cooperation Council (GCC) region, surveillance remains fragmented despite growing evidence of high resistance burdens. This systematic review aimed to synthesize data on the prevalence and patterns of antimicrobial-resistant organisms in tertiary-care settings across Gulf countries. Learn More MK-20-11-2024-2111 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) New Coronavirus Pandemic Worldwide: Some Lessons From Covid-19 Control The aim of the study was to perform a comparative analysis of COVID-19 epidemic process in selected countries of the world during the first pandemic wave in 2020 and during the rise of SARS-CoV2 variant Omicron. Analysis of the COVID-19 epidemic process was based on data from the Wordometers website (https://www.worldometers.info/coronavirus/#countries). In addition, scientific and popular science articles and official documents on the history, epidemiology, and response to the pandemic in different countries of the world in 2020-2022 were analyzed. Learn More MK-20-11-2024-2111 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Comparative Effectiveness of Pain Management Strategies During Labor and Delivery Labor pain is widely recognized as one of the most intense forms of pain experienced by women, significantly impacting the birthing experience. Effective pain management during labor is essential not only for maternal comfort and satisfaction but also for favorable obstetric outcomes. A wide range of pharmacological and non-pharmacological strategies are used worldwide, yet comparative effectiveness remains under-investigated, particularly in the Saudi Arabian context. Learn More MK-20-11-2024-2119 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Review of the Effectiveness of Health Education and Promotion Strategies in Preventing Respiratory Infectious Diseases Respiratory infectious diseases (RIDs), such as influenza, tuberculosis, and COVID-19, pose a significant global public health challenge due to their high transmissibility and morbidity. Health education and promotion strategies are critical for preventing RIDs, yet gaps in implementation and effectiveness persist. This review aims to evaluate the effectiveness of health education interventions in reducing the incidence of RIDs, improving knowledge, and fostering preventive behaviors. Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) MK-20-11-2024-2124 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Workplace Modifications to Improve Occupational Health and Prevent Musculoskeletal Disorders in Health Professions Musculoskeletal disorders (MSDs) and renal side effects among healthcare workers (HCWs) are major occupational health concerns. These conditions are often exacerbated by long working hours, high physical demands, and insufficient ergonomic interventions. In an effort to reduce the burden of these health issues, workplace modifications such as ergonomic interventions, hydration protocols, and adjustable workstations have been widely studied. However, the effectiveness of these interventions in preventing musculoskeletal and renal disorders remains unclear, particularly within healthcare settings. Learn More Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Review of the Adverse Effects of Prolonged Pain Relief Use in Diabetic Patients Diabetic neuropathic pain is a prevalent and debilitating complication of diabetes mellitus, often necessitating prolonged use of pain relief medications. While these medications are effective in managing pain, their extended use may lead to adverse effects, complicating diabetes management. This systematic review aims to evaluate the side effects associated with prolonged use of pain relief medications in diabetic patients. A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Cochrane Library. MK-19-11-2024-2126 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Artificial Intelligence in Healthcare: A Multidisciplinary Approach to Patient-Centered Care Artificial intelligence (AI) is rapidly transforming healthcare, offering unprecedented potential to enhance diagnostics, personalize treatments, and optimize workflows. However, the ethical and effective implementation of AI hinges on multidisciplinary collaboration and patient-centered care. This systematic review aims to synthesize existing research on AI applications in healthcare, focusing on how multidisciplinary approaches influence its impact on patient-centered care. A systematic review was conducted following PRISMA guidelines. Electronic databases (PubMed, Scopus, Web of Science, Embase, IEEE Xplore) were searched using predefined keywords related to AI, healthcare settings, and patient-centered care. Studies published in English from January 2010 to August 2024 were included. MK-19-11-2024-2123 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Structure And Dynamic Of Acute Poisonings In The City Of Ryazan In 2016-2021 To analyze a structure of acute poisonings in the city of Ryazan in 2016-2021; to identify a summary dynamic of poisonings and poisonings classified according to separated toxicants, as well as sex characteristics. Investigation materials – maps of ambulance crew calls in the city of Ryazan in 2016-2021. An analysis of statistic data collected in 2016-2021 showed a derision of ambulance calls for victims with acute poisonings. In Ryazan, as well as in Russia at all, alcohol poisonings and toxic spirits poisonings prevailed. Learn More MK-20-11-2024-2122 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Organization And Provision Of Specialized Medical Treatment For Victims With Burns To research the conditions of organization and provision of specialized medical treatment on the profile “surgery (combustiology)” basing on the data from informational-analytic system “Combustiological treatment in Russia”. In the basis of research – reports from 120 medical treatment organizations (MTO) in the year 2021 and some date from previous years reports. In 2021 in the Russian Federation a specialized treatment for victims with burns was pro- vided in 63 burns departments/centers, including 7 children departments/centers, and on profiled burns bunks i Learn More MK-20-11-2024-2119 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Treatment Of Patients With Concomitant Trauma To The Organs Of Several Cavities And To The Musculoskeletal System To improve the results of treatment of patients with severe combined trauma of the organs of several cavities (skull, thoracic and abdominal cavities, retroperitoneal space) and of the musculoskeletal system. The study involved 72 patients treated between 2013 and 2017 in a Level I trauma center established at the Republican Clinical Hospital of the Ministry of Health of the Kabardino-Balkarian Republic. The Injury Severity Score (ISS) index was used to determine the severity of injury. Learn More MK-20-11-2024-2115 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Impedance Spectrometry As A Promising Method To Assess The Effects Of Parametric And Shock-Acoustic Effects Of Non-Lethal Systems The aim of the study is to adapt the method of impedance spectroscopy as applied to the assessment of possible effects of acoustic impact of various parameters. The study was carried out using 70 rabbits (chinchilla) weighing 2.5-3 kg. Five experimental and control groups were formed based on a preliminary examination of the animals in order to cull individuals with altered acoustic stem evoked potential and other parameters. The experimental animals were exposed to five series of 160 acoustic pulses with low-frequency spectrum each. Learn More MK-20-11-2024-2126 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) The Impact of Shift Work and Long Working Hours on the Mental Health of Healthcare Professionals Shift work and long working hours are increasingly common in healthcare settings, yet their potential impact on the mental health of healthcare professionals remains a significant concern. Previous studies have suggested that shift work and extended working hours may contribute to elevated risks of mental health issues such as depression, anxiety, and sleep disorders. However, the evidence remains mixed, and there is a need for a comprehensive synthesis of the available literature to clarify these associations. Learn More MK-23-11-2024-2143 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Medical Care For Children Affected By Armed Conflict: A Systematic Literature Review The aim of the study is to analyze the data on mortality, structure of injuries, terms of hospitalization, routing of patients and organization of medical care for children injured in armed conflicts and terrorist acts. A systematic review was performed in accordance with the recommendations of the PRISMA protocol. A comprehensive search was conducted in PubMed, ScienceDirect, E-library, and GoogleScholar databases for the period from 1995 to 2022. Learn More MK-23-11-2024-2141 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) The Role Of The Operational And Management Service In Responing To Emergency Situations In Treatment Medical Organizations Of The Moscow Health Department The purpose of the study is to determine the role of the operational administrative service (ORS) of the Moscow Department of Health (DZM) in responding to emergency situations (ES) in medical organizations (HMO) of the Moscow Department of Health. Reports from medical organizations of the Department of Health to the operational administrative service about emergency situations and official reports of line control doctors (LC) to the ORS in 2021–2022. Learn More MK-23-11-2024-2140 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Operation Of The Joint Emergency Medical Service And Disaster Medicine Service In Conditions Of Protracted Emergency Situation Of Biological And Social Character The purpose of the study is to use the example of the Belgorod region to analyze the functioning of the organization- al model of the activities of the joint emergency medical service (EMS) and the Disaster Medicine Service (MSS) in 2019–2022 against the backdrop of a protracted emergency situation (ES) of a biological and social nature. The research materials are data from the annual reports of the operational department of the joint EMS and QMS service, as well as quarterly and annual reports of medical organizations (HMOs) in the region. MK-23-11-2024-2136 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Issues Of Readiness Of Nursing Personnel To Provide Medical Care In Conditions Of Mass Admission Of Victims In Emergency Situations To Medical Organizations The purpose of the study is to analyze the need to train medical workers with secondary medical education in order to ensure their readiness to provide medical care in conditions of mass admission of victims in emergency situations (emergency situations) to medical treatment organizations (HMOs). The research materials are the results of a survey of nurses at a large multidisciplinary medical facility in the city of Orenburg regarding their subjective assessment of their own level of skills and the need for further improvement of labor functions. Learn More MK-23-11-2024-2133 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Dispatcher Support For The Provision Of First Aid By Eyewitnesses Of The Event During Out-Of-Hospital Circulatory Arrest In A Victim: Reality And Prospects Purpose of the study. The purpose of this work is to analyze the practical experience of remote support of first aid in out- of-hospital circulatory arrest using the example of the State Budgetary Institution of Health “Emergency Station of the Gelendzhik Resort City” of the Ministry of Health of the Krasnodar Territory. The empirical basis of the scientific research was the analytical material on dispatching support for the pro- vision of first aid in case of out-of-hospital circulatory arrest, contained in the works of Russian and foreign scientists. MK-23-11-2024-2134 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Analysis Of Risks Of Terrorism For The Population Of A Several Countries And The World Population In General, 2011–2020 The objectives of the study are to study the risk indicators of terrorism for the population of a number of countries and the world population as a whole, as well as their dynamics in 2011–2020 in order to determine the average annual risk of being exposed to a terrorist attack, dying or being harmed to life and health. Indicators of the open Global Terrorism Database (GTD), which was created, continues to be created and improved by employees of the National Consortium for the Study of Terrorism and Responses to Terrorism (START) of the University of Maryland (University of Maryland) Learn More MK-23-11-2024-2133 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Dispatcher Support For The Provision Of First Aid By Eyewitnesses Of The Event During Out-Of-Hospital Circulatory Arrest In A Victim: Reality And Prospects Purpose of the study. The purpose of this work is to analyze the practical experience of remote support of first aid in out- of-hospital circulatory arrest using the example of the State Budgetary Institution of Health “Emergency Station of the Gelendzhik Resort City” of the Ministry of Health of the Krasnodar Territory. The empirical basis of the scientific research was the analytical material on dispatching support for the pro- vision of first aid in case of out-of-hospital circulatory arrest, contained in the works of Russian and foreign scientists. Learn More MK-23-11-2024-2132 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Emergency Risk Communication In Providing Of Medical Care To Victims Of Emergency Situations The purpose of the study is to study domestic and foreign experience in implementing risk communications in providing of medical care to victims of emergency situations (ES). Domestic and foreign publications on the problem of using risk communications in emergency situations. During the period of liquidation of the consequences of emergencies, especially those that are characterized by scale and wide public resonance, issues of information support of the population and medical personnel become of utmost importance. Learn More MK-23-11-2024-2127 / Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Analysis Of The Results Of Intraosseous Vascular Access Using Various Devices In Emergency Medical Care The purpose of the study is to assess the effectiveness of intraosseous vascular access in the provision of emergency medical care in emergency situations and military conflicts on the example of the Belgorod region. Domestic regulatory framework for the use of intraosseous vascular access; assessment of the design and operational characteristics of the domestic “UVK M intraosseous cannulation device”; experience in using VKSD and devices for its implementation by personnel of the SMP station of the Belgorod region in 2022–2023. Learn More Information for Authors Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) is a publisher of scholarly open accessjournals. All journals uphold a peer-reviewed, rapid, and rigorous manuscript handling and editorial process Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) journals are the perfect place for you to publish your work under an open access license, in a fast and straightforward manner. Our journals are indexed in the leading databases and, since they are open access, have a broad readership Why with us? We provide the widest variety of journals for publishing your articles. All journals are Open get right of entry to and as soon as everyday your article can be on-line for viewing and downloading on the earliest. No area constraints or colour figure expenses. Your work is greater seen and effect is assured. We unfold your article via Scribd, Twitter, facebook, and other social media websites except traditional repositories and indexes.average papers gets hundreds of perspectives and masses of downloads within weeks 1. We provide the widest range of journals for publishing your articles. All journals are Open get entry to and once widely wide-spread your article might be online for viewing and downloading at the earliest. No space constraints or colour discern prices. We provide the widest range of journals for publishing your articles. All journals are Open get entry to and once widely wide-spread your article might be online for viewing and downloading at the earliest. No space constraints or colour discern prices. Your paintings is extra visible and impact is assured. We spread your article thru Scribd, Twitter, facebook, and different social media web sites besides conventional repositories and indexes. common papers receives hundreds of perspectives and loads of downloads inside weeks. Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) monthly based publication with peer reviewed process and fast publication record. achieving to extra targeted and non-targeted target audience concurrently offer the authors their due credibility in conjunction with reputation many of the scholars working on the identical subject. then again, precious medical data reaches to academicians who are not able to undergo the subscription costs and examine the articles Guidelines for authors Perception medical Publishing (Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966)) journals convey articles in all regions related to remedy, clinical, clinical, Dental, Nursing and lots of more. Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) welcomes the submission of manuscripts that meet the overall criteria of significance and medical excellence. Papers might be posted approximately 15 days after acceptance. As a member of publisher international Linking association, PILA, Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) follows the innovative Commons Attribution License and pupils Open get right of entry to publishing policies. Editorial guidelines and system Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) journals follow a innovative editorial policy that encourages researchers to publish the unique studies, opinions and editorial observations as articles, nicely supported by using tables and photograph representation. Submission Article submissions must be done the use of the online Editor manager system or via e mail IDs furnished at the respective magazine’s website online. Resubmission If you have altered your paper in mild of the peer reviewer’s comments and you have written a covering letter to the editor explaining the adjustments you made or refuting the reviewer’s remarks, you're ready to resubmit. try to resubmit as quickly as you can. generally, this makes it easier to do because the paper is still clean in your thoughts. The clinical world actions right away so that you want your paintings posted before a person else produces similar work. as soon as you have got resubmitted you'll see the status of the paper modified inside a selected span of time. in case you don’t see this or don’t get hold of any acknowledgment of your resubmission, please check with the Editorial body of workers and verify the receipt of the thing by means of the Editorial office. Submission recommendations Article submissions must be done the use of the online Editor manager system or via e mail IDs furnished at the respective magazine’s website online. Contents Any manuscript submitted to any Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) journal need to be unique. The manuscript, or extensive parts of it, need to not be under attention via another journal/writer. anyhow in which there's the capability for overlap or duplication transparency from the authors is obligatory. Any doubtlessly overlapping guides must be declared on submission and, wherein possible, uploaded as extra files with the manuscript. Any overlapping publications must be noted. The Editors of Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) journals reserve the right to judge potentially overlapping or redundant publications on a case-by-case foundation. Format Most articles published in Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) Journals might be organized into the following sections: title, authors, affiliations, abstract, introduction, techniques, effects, dialogue, references, acknowledgments, determine legends and table captions. Uniformity in format will assist readers and customers of the magazine. We understand, but, this layout is not perfect for all sorts of research. if you have a manuscript that would gain from a special format, please contact the editors to speak about this further. although, we don't have any company duration regulations for the entire manuscript or character sections, we urge authors to offer and speak their findings concisely along side renovation of a logical waft. Paper Template All manuscripts are subjected to RAPID peer review process and those of high quality (which are not previously published and are not under consideration for publication by another journal) would be published without any delay in subsequent issue. Note: Please submit your manuscript both in doc or docx and PDF format, and follow the Medicina Katastrof (ISSN:2070-1004) (E-ISSN:2686-7966) paper template. Download Paper Formate Discussion The dialogue ought to be concise and tightly argued. It ought to start with a brief summary of the primary findings. It have to encompass paragraphs at the generalizability, medical relevance, strengths, and, most significantly, the limitations of the take a look at. you may want to speak about the following points also. How do the conclusions affect the prevailing understanding inside the subject? How can destiny research build on these observations? What are the important thing experiments that have to be done? Acknowledgments Individuals who contributed to the work, however do no longer healthy the criteria for authors need to be listed within the Acknowledgments, along side their contributions. You need to additionally ensure that all people named inside the acknowledgments is of the same opinion to being so named. details of the funding resources that have supported the work need to be restrained to the investment statement. Do no longer consist of them inside the Acknowledgments. Abbreviations Please hold abbreviations to a minimum. listing all non-popular abbreviations in alphabetical order, at the side of their increased shape. outline them as nicely upon first use within the text. Non-widespread abbreviations ought to no longer be used until they appear at the least three times within the text.
Psychological Interventions for Post-Traumatic Stress Disorder in Military Personnel using Artificial Intelligence
Background: Post-traumatic stress disorder is prevalent in active-duty military personnel and veterans, and access to trauma-focused psychotherapy is limited by workforce capacity, operational demands, and stigma. Artificial intelligence-enabled technologies may enhance delivery and engagement. Methods: PubMed was searched for randomized trials or comparative cohort studies of artificial intelligence–enhanced psychological interventions for post-traumatic stress disorder in active-duty personnel or veterans. Screening, data extraction, and risk-of-bias appraisal were conducted in duplicate, and findings were synthesized narratively without meta-analysis. Results: Eleven studies (9 randomized trials, 2 nonrandomized studies) were included, mainly immersive virtual reality exposure variants and motion-assisted reconsolidation approaches. Virtual reality–graded exposure improved response versus usual care (≥30% Clinician-Administered PTSD Scale reduction: 7/10 vs 1/9; RR 3.2), and motion-assisted therapy in treatment-resistant veterans reduced clinician-rated symptoms versus control (mean difference −9.38 points; 95% CI −17.33 to −1.44). An intensive multicomponent trauma management program reported large improvement (effect size 2.06) and 65.9% no longer meeting diagnostic criteria, while dropout in exposure-based trials reached 4-44%. Conclusions: Artificial intelligence-enabled interventions were associated with clinically meaningful post-traumatic stress disorder symptom reductions, but heterogeneity and adherence constraints limited certainty. Larger pragmatic trials with standardized outcomes, safety reporting, and longer follow-up are needed.
Abdulrahman Saud Alharbi¹, Khalid Abdullah Alahmari¹, Dhafer Ali Alshehri¹, Abdullah Mohammed Alsubaie², Turki Mohammed Albaqami², Nader Marzouq Alotaibi³
Imaging-Based Changes in Visceral Adipose Tissue and Metabolic Risk: A Systematic Review
Background: Visceral adipose tissue is a high-risk fat compartment linked to insulin resistance, dyslipidaemia, and hepatic steatosis. Imaging enables direct quantification of visceral adipose tissue and depot-specific change. Methods: PubMed was searched for human clinical trials and longitudinal cohorts reporting serial visceral adipose tissue quantified by magnetic resonance imaging, ultrasonography, or dual-energy X-ray absorptiometry and at least one metabolic outcome. Reference lists were hand-searched, screening and data extraction were performed in duplicate, and findings were synthesised narratively without meta-analysis. Results: Thirteen studies (10 trials, 3 cohorts; sample size 32–598; follow-up 8 weeks–2 years) were included, most commonly reporting glycaemic or insulin-resistance indices, lipid profile measures, and hepatic fat. In a cohort, each 10 cm² increase in visceral adipose tissue was associated with higher odds of metabolic syndrome (odds ratio 1.23; 95% confidence interval 1.09–1.39). In randomised trials, dapagliflozin reduced visceral adipose tissue volume by 0.35 L and liver fat by 3.74 percentage points versus placebo (8 weeks), and semaglutide reduced visceral fat mass by 27.4% versus 2.4% (68 weeks). Conclusions: Imaging-detected reductions in visceral adipose tissue were generally accompanied by improved metabolic risk markers, with the most consistent co-improvements in hepatic fat and lipid risk. Standardised imaging protocols and longer multicentre studies are needed to define clinically meaningful thresholds of visceral adipose tissue change across modalities.
Zainab Jawad Aljumah¹, Fatimah Abdulmajeed Ali Almousa², Amal Essa Ali Al Abdulghani³, Arwa Jamal Ali Alameer⁴, Abdullah Eissa Ali Aalsaheeh⁵, Yasir Saeed Almutairi⁶, Ahmed Saleh Serhan Alghamdi⁷
Prehospital Teleconsultation and Imaging-Guided Destination Choice: A Systematic Review
Background: Prehospital destination decisions determine timely access to definitive imaging and reperfusion pathways for acute stroke, myocardial infarction, and other emergencies. Teleconsultation with prehospital diagnostic transmission may reduce uncertainty and enable direct routing to capable centers. Methods: PubMed was searched for English-language human studies evaluating prehospital teleconsultation plus diagnostic transmission (computed tomography–enabled stroke models, point-of-care imaging, or electrocardiogram transmission) that influenced hospital destination choice or pathway activation. Clinical trials and cohort studies were included, data were extracted in duplicate, and results were synthesized narratively without meta-analysis. Results: Eleven studies were included. In stroke, a mobile computed tomography pathway reduced call-to-therapy-decision time by 41 minutes (35 vs 76 minutes; 95% confidence interval 36–48) and ambulance-based thrombolysis reduced alarm-to-thrombolysis time by 25 minutes (interquartile range 13–34); onset-to-thrombolysis time was 72 vs 108 minutes in a multi-center controlled study. Disability outcomes favored mobile imaging dispatch in large cohorts (common odds ratio for worse disability 0.71; 95% confidence interval 0.58–0.86), and in ST-segment elevation myocardial infarction, telecardiology-supported electrocardiogram transmission increased direct catheterization-laboratory routing to 69.8% and reduced system delay (76 vs 90 minutes) and door-to-balloon time (57.78 vs 141.70 minutes). Conclusions: Teleconsultation paired with actionable diagnostic transmission shortened key system delays and improved destination-pathway alignment, with the most reproducible benefits in imaging-enabled stroke and telecardiology-supported myocardial infarction networks.
Ali Ebrahim Saleh Al-Mahfoodh¹, Majed Dhaifallah Matar Al-Mutairi², Mohamed Alawai Alsaid Ali³, Eman Mohammed Al-Gharqan⁴, Ghanem M. Al-Qahtani⁵, Hydar Abdulla Ali Al-Nahwi⁶, Wala Zaki Al-Jamea⁷
Robotic Chest-Compression Systems with Real-time Physiologic Feedback: A Systematic Review of Closed-Loop and Machine-Learning Approaches
Background: Mechanical chest-compression devices standardize cardiopulmonary resuscitation (CPR), but fixed compression parameters may not match patient physiology. Robotic and algorithm-driven systems that use real-time physiologic signals could enable closed-loop CPR optimization. Methods: PubMed was searched from database for clinical, preclinical, and modeling studies evaluating robotic/mechanical chest-compression systems incorporating real-time physiologic feedback (e.g., end-tidal carbon dioxide [ETCO₂], arterial pressure, coronary perfusion pressure [CPP], carotid flow) consistent with closed-loop or machine-learning approaches. Eligible studies were synthesized narratively without meta-analysis. Results: Five studies met inclusion: two randomized porcine trials, one porcine machine-learning modeling study (n=7), and two simulation/model studies. A closed-loop machine-controlled CPR system sustained higher CPP at 30 minutes versus guideline CPR (22±3 vs 8±3 mmHg) and preserved carotid blood flow during prolonged resuscitation. An AI-driven CPR robot achieved similar hemodynamics to a standard piston device, with no difference in carotid flow (−23.2±20.2 mL/min; P=0.250) and comparable ROSC (83.3% vs 66.7%; P=1.00). Simulation studies suggested that CPP-targeted controllers improved modeled flow/ETCO₂, and an ML model predicted carotid flow per compression with high accuracy (R²=0.96). Conclusions: Evidence for physiologic-feedback robotic CPR is limited to preclinical and simulation studies, but supports technical feasibility and potential hemodynamic advantages over fixed-parameter CPR. Human feasibility trials with standardized ventilation, safety outcomes, and neurologic endpoints are required before clinical deployment.
Salem Ahmed Al-Joud¹, Shadi Ahmed Alghamdi², Fahad Mohammed Alshamrani³, Khaled Hashem Almalawi⁴ Turki Rajah Alharbi⁵, Marwan Hamed Rasheed Alsulami⁶, Bandar Mohammed Al-Zahrani⁷, Sultan Shulaywih Hiraz Alsulami⁸
Central Line-associated Bloodstream Infection in Surgical Patients: Impact of Ultrasound Guided Insertion
Background: Central line–associated bloodstream infection (CLABSI) remains a major preventable complication in surgical and perioperative care. Ultrasound guidance improves central venous catheter (CVC) placement safety, but its effect on CLABSI is unclear. Methods: PubMed was searched using systematic search strategy with humans and English filters. Randomized trials and cohort studies comparing real-time ultrasound-guided versus landmark CVC insertion in surgical/perioperative or surgical-critical-care patients (adults and children) were included, and findings were synthesised narratively without meta-analysis. Results: Of 1,183 records identified, 273 duplicates were removed; 910 titles/abstracts were screened and 58 full texts assessed, yielding 9 included studies. Ultrasound guidance increased cannulation success with improved first-pass performance, and reduced mechanical complications (e.g., carotid puncture 1.7% vs 8.3%). Infection outcomes were heterogeneous: one trial reported lower catheter-associated bloodstream infection (10.4% vs 16.0%), a prospective cohort found no association (hazard ratio 0.69; 95% CI 0.36–1.30), whereas a post hoc analysis reported higher CRBSI hazard with ultrasound (hazard ratio 2.21; 95% CI 1.17–4.16). Conclusions: Ultrasound-guided CVC insertion consistently improved procedural performance and reduced mechanical harm, while evidence for CLABSI/CRBSI reduction was inconsistent and context dependent. Ultrasound should be implemented as the default insertion approach within comprehensive insertion-and-maintenance bundles for surgical patients.
Mohammed Taher Abdullah Alshabaah¹, Ismail Nori Hassan Albdul Almohsin², Mohammed Essa Hussin Alsarouj³, Hussein Abdulmohsen Hussein Almurahail⁴ Zaher Ahmed Essa Albeladi⁵, Omar Khalaf Alzahrani⁶, Faisal Hassan Ali Alhassan⁷, Mohammed Rajan Al Ajmi⁸
Perioperative Pulmonary Rehabilitation Interventions to Reduce Postoperative Pulmonary Complications After Thoracic Surgery
Background: Postoperative pulmonary complications are common after thoracic surgery and contribute to morbidity and longer hospital stay. Perioperative pulmonary rehabilitation aims to reduce these complications, but the relative benefit of different approaches is uncertain. Methods: PubMed was searched from inception to July 2025 for comparative clinical trials and cohort studies evaluating perioperative pulmonary rehabilitation interventions in adults undergoing thoracic surgery. Findings were synthesised narratively without meta-analysis; postoperative pulmonary complications were the primary outcome, with length of stay and functional recovery as secondary outcomes. Results: Eleven studies (eight randomised trials, two cohorts, one case-control; sample size range 12–1056) were included. Enhanced recovery after surgery plus pulmonary rehabilitation reduced postoperative pulmonary complications versus enhanced recovery alone (n=374; 18.7% vs 33.2%; hazard ratio 0.52, 95% confidence interval 0.35–0.79). Ultra-early post-anaesthesia care unit rehabilitation reduced atelectasis and/or pneumonia (n=900; 6.7% vs 11.4%; odds ratio 0.53, 95% confidence interval 0.26–0.98), preoperative high-intensity interval training reduced pulmonary complications (n=151; 23% vs 44%), and a pilot preoperative pulmonary rehabilitation programme shortened postoperative stay (7.8 ± 4.8 vs 12.2 ± 3.6 days). Conclusions: Bundled perioperative pulmonary rehabilitation, especially when integrated into enhanced recovery pathways and delivered with very early mobilisation, was associated with fewer postoperative pulmonary complications after thoracic surgery. Standardised endpoint definitions and pragmatic comparative trials are needed to refine patient selection and intervention dosing.
Ali Hussain Al Ahmad¹, Dawood Ali Almasoud², Nesren Salman Al Ismail³, Ali Salman Atehaifah⁴ Durgham Ibrahim Alalawi⁵, Khadijah Saeed Alshokai⁶, Randa Ahmed AlRaja⁷
Effect of Metformin versus Sodium Glucose Cotransporter-2 Inhibitors in Diabetic Patients with Chronic Kidney Disease: A Systematic Review
Background: Diabetic chronic kidney disease carries high risks of kidney failure and cardiovascular events, and clinicians frequently weigh metformin-based care against sodium–glucose cotransporter 2 inhibitor therapy for renoprotection. Methods: PubMed was searched from inception to August 2025 (English-language, human studies) for trials and cohort studies in adults with diabetes and chronic kidney disease evaluating metformin strategies and/or sodium–glucose cotransporter 2 inhibitors. Studies reporting kidney progression and cardiovascular or mortality outcomes were narratively synthesized (no meta-analysis). Results: Six studies were included: three randomized trials (n=4,304; n=4,401; n=6,609) and three population-based cohort studies (n=1,450; n=45,545; n=4,278). Sodium–glucose cotransporter 2 inhibitors reduced composite kidney outcomes in trials (hazard ratios 0.61 [95% confidence interval 0.51–0.72], 0.70 [0.59–0.82], and 0.72 [0.64–0.82]) and lowered kidney-related adverse events in advanced chronic kidney disease (odds ratio 0.48 [0.33–0.71]). In comparative cohorts, metformin plus sodium–glucose cotransporter 2 inhibitors reduced composite kidney outcomes (adjusted hazard ratio 0.65 [0.48–0.87]) and all-cause mortality (0.74 [0.64–0.84]) versus sodium–glucose cotransporter 2 inhibitors alone, with lower severe acute kidney injury (0.72 [0.54–0.96]) and metabolic acidosis (0.58 [0.40–0.83]); stopping metformin at stage 4 chronic kidney disease increased mortality (hazard ratio 1.26 [1.10–1.44]). Conclusions: Sodium–glucose cotransporter 2 inhibitors showed consistent kidney protection, while observational evidence supported continued metformin, especially in combination, when kidney-function–based safety monitoring is feasible in routine practice.
Sodium-glucose cotransporter 2 inhibitors
Qasim Hussain Mohsen ALHulyami¹, Arwa Ahmed Abdulkareem Alhajji², Mohammed Fahad Abdulwahab Almomen³, Mustafa Ahmed Aish BuSaleh⁴, Bandar Hamdan Mohaimeed Alnefaie⁵, Narjes Ali Nasser AL Shawareb⁶, Mona Ali Alwaif⁷
Fall-Prevention Programs for Older Adults Presenting With an Index Fall: Effectiveness and Safety
Background: Older adults discharged after an index fall emergency presentation face high risks of recurrent falls, injury, and repeat acute-care use; the effectiveness and safety of emergency-linked prevention programs remains uncertain. Methods: PubMed was searched from inception to July 2025. Randomized controlled trials of fall-prevention programs initiated at, or directly triggered by, the index-fall emergency encounter were included and synthesized narratively. Results: Eight randomized trials (n=2,806; follow-up 6–12 months) assessed emergency-department–initiated interdisciplinary assessment/referral, structured rehabilitation, patient-centred coaching, or emergency-department multidisciplinary consultation. Recurrent falls effects were mixed, ranging from reduced recurrent falling with comprehensive assessment (odds ratio 0.39; 95% CI 0.23–0.66) to no benefit in cognitive impairment/dementia (risk ratio 0.92; 95% CI 0.81–1.05) and neutral referral-based results for fallers (risk ratio 1.11; 95% CI 0.95–1.31). Secondary outcomes showed selective benefit, including reduced falls rate with coaching (incidence rate ratio 0.65; 95% CI 0.43–0.99), fewer fractures (incidence rate ratio 0.37; 95% CI 0.15–0.91), and fewer subsequent ED visits with multidisciplinary consultation (incidence rate ratio 0.47; 95% CI 0.29–0.74) including fall-related ED visits (incidence rate ratio 0.34; 95% CI 0.15–0.76). Conclusions: Emergency-linked fall-prevention programs demonstrated variable effectiveness, with more consistent benefits when risk assessment was coupled with active follow-up and service linkage. Caregiver-integrated pathways may be required for cognitively impaired populations
Majed Helal Almutairi¹, Hussain Mohammad Saud Azbaiyel², Mahdy Saeed Alqahtani³, Salha Abdul Aziz Al-Suhaimi⁴, Bashayer Saleh Al-Shammari⁵, Khulud Abdullah Bin Awdhah⁶, Lamis Ahmad Jabali⁷
Mechanical Mobility-Assist Devices and Ergonomic Programs in Nursing Homes for Preventing Staff Musculoskeletal Disorders: A Systematic Review
Background: Work-related musculoskeletal disorders (MSDs) are common among nursing-home staff and are strongly linked to resident handling, transfers, and repositioning. Mechanical mobility-assist devices and ergonomic safe resident-handling programs are widely implemented, but nursing-home–specific effectiveness remains variably reported. Methods: PubMed was searched from inception to September 2024 for English-language human studies in nursing homes or comparable long-term care facilities. Clinical trials, controlled before–after studies, and cohort evaluations reporting staff MSD outcomes were eligible; risk of bias was assessed using design-appropriate checklists and results were synthesized narratively. Results: Eleven studies were included. A nursing-home best-practices program reduced workers’ compensation claims (rate ratio 0.39; 95% CI 0.29–0.55), recordable injuries (0.54; 95% CI 0.40–0.73), and first reports of injury (0.65; 95% CI 0.50–0.84). Ceiling-lift interventions reduced lifting/transferring injuries by 58% per 100,000 work-hours (p=0.011) with reported payback periods of 0.82–2.50 years, and in a cluster trial (n=594) low back pain days decreased by 0.8 (95% CI −1.19 to −0.38) and worst-pain intensity by 0.4 points (95% CI −0.60 to −0.26) on a 0–10 scale; observational follow-up showed frequent lift use was protective (RR 0.39; 95% CI 0.18–0.84) and physical workload decreased by 24% among nursing assistants. Conclusions: Benefits were most consistent when devices were embedded within sustained ergonomic programs ensuring availability, competency-based training, maintenance, and monitoring
Yara Mohammed Alanzi¹, Sukut Omar Alanazi 2, Nidaa Abdullah Salamaa Aljuwaybiri 3, Maznh Ibrahim Khazen Alanzi 3, Haneen Ibrahim Alhaddad 3, Dalal Abdullah Salmaa Aljuwaybiri 3, Waad Atallah Aljuhani 3
Mechanical Chest Compression Devices Versus Manual Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: A Systematic Review
Background: Out-of-hospital cardiac arrest (OHCA) remains a major cause of global mortality, and high-quality chest compressions are critical for survival. Mechanical chest compression devices were developed to standardize compression depth and rate, reduce rescuer fatigue, and enable continuous compressions during transport. However, their routine clinical effectiveness compared with manual cardiopulmonary resuscitation (CPR) remains uncertain across emergency medical systems. Methods: A systematic review of PubMed and related databases was performed following PRISMA 2020 guidelines. Eligible studies were randomized or comparative cohort designs evaluating mechanical versus manual chest compressions in adult OHCA. Data were extracted independently, and outcomes were summarized narratively without meta-analysis. The primary outcomes were survival to hospital discharge and favourable neurological recovery (Cerebral Performance Category); secondary outcomes included return of spontaneous circulation (ROSC) and CPR process quality. Results: Eleven studies met inclusion criteria (four randomized trials, seven observational cohorts) encompassing more than 20,000 OHCA patients. Across major randomized trials, survival to discharge did not differ significantly (6-11% mechanical vs 7-11% manual; pooled adjusted odds ratio 1.0, 95% confidence interval 0.8-1.3). Neurologically favourable survival showed no consistent benefit, and some registries reported worse outcomes with device use (adjusted relative risk 0.41-0.70). Secondary outcomes demonstrated improved compression fraction but no improvement in ROSC or 30-day survival. Conclusions: Routine mechanical CPR did not improve survival or neurological outcomes compared with high-quality manual CPR. Device use should be reserved for contexts where manual compressions are unsafe or impractical, supported by strict training and monitoring.
Ultrasonography, Emergency Medical Services, Trauma, Triage, Diagnostic Imaging, Patient Outcome Assessment.
Raed Thawab Aljuaid¹, Mohammed Salman AL Alsaraie², Sami Ahmed Alzahrani³, Abdulelah Turki Alanazi⁴, Ibrahim Suwailem Alatawi⁵, Ibrahim Mohammed Alnashri⁶, Ahmad Mohammed Abdullah Alahmari⁷
Operating Room and Door-Opening Control Strategies to Reduce Intraoperative Microbial Contamination: A Systematic Review
Background Microbial contamination of operating room air is a modifiable contributor to surgical site infection risk. Door-opening behaviour and staff traffic are thought to disrupt pressure and airflow, yet the impact of specific door-opening control strategies on intraoperative contamination has remained uncertain. Methods A systematic review of PubMed, Scopus and Web of Science was conducted from inception to May 2025. Clinical trials, quasi-experimental studies and observational cohorts in human operating rooms were eligible if they quantified intraoperative airborne microbial or particle contamination in relation to door-opening frequency or a defined door-opening control strategy. Primary outcomes were intraoperative airborne microbial load (colony-forming units per cubic metre) and particle counts; secondary outcomes included door-opening rate and surgical site infection incidence. Results Ten studies were included across observational cohorts, higher door-opening rates and greater numbers of personnel were consistently associated with increased airborne contamination; one study reported mean 328 CFU/m³ with 84% of samples above 180 CFU/m³ in high-traffic theatres, and another found traffic flow explained 68% of CFU variance. Interventions such as access signage, staff education and multimodal quality-improvement programmes reduced door-opening rates by about 20-40% and lowered particle counts in the sterile field by up to 40%. Conclusions Door-opening frequency and operating room traffic are consistently associated with higher intraoperative airborne contamination, and simple door-control strategies can meaningfully reduce traffic and environmental bioburden; their independent effect on surgical site infections remains uncertain and warrants robust prospective evaluation.
Mohammed Awadh Al Mashhur¹, Yousef Abdulhadi F. Alawad², Wesam Talat A. Alnemari³, Raad Mohammed Alghamdi⁴, Jaber Ali Hussain Absi⁵, Dhawi Talaq Dhawi Alotaibi⁶
Diagnostic Accuracy and Safety of High-Sensitivity Troponin Algorithms for Early Exclusion of Acute Coronary Syndrome
Background: High-sensitivity cardiac troponin (hs-cTn) algorithms are increasingly used to rapidly exclude acute coronary syndrome (ACS) in emergency departments, but their diagnostic accuracy, safety and effects on patient flow remain uncertain. Methods: Electronic databases were searched from inception to August 2024 for prospective cohorts and trials of adults with suspected ACS managed using predefined hs-cTn accelerated diagnostic pathways. Studies had to report diagnostic accuracy for myocardial infarction (MI) and at least one short-term safety outcome; data were extracted and risk of bias was judged with QUADAS-2. Results: From 2,743 records, 13 studies (10 cohorts, 3 trials; >80,000 participants) were included. hs-cTn 0/1-hour and 0/2-hour algorithms ruled out MI in roughly 40-60% of emergency-department patients, with rule-out sensitivity 98-100% and negative predictive value 99.0-99.9%. Among rule-out patients, 30-day MI or cardiac death was ≤1.0% (often 0.0-0.4%). Implementation trials showed shorter emergency-department stays (about 10.1 to 6.8 h) and higher direct discharge rates (50-71%) without significant 30-day major adverse cardiac events; performance was weaker in some high-risk subgroups, particularly those with known coronary artery disease. Conclusions: The hs-cTn-based accelerated diagnostic pathways provided very high sensitivity and negative predictive value for early exclusion of MI, with consistently low short-term event rates and improved emergency-department efficiency, but conservative application and local validation are advisable in high-risk populations and new healthcare settings.
Zahra Hussin Eisaa Alhazmi¹, Azizah Nasser hussin Altherwi², Sarah Nasser Hussin Altherwi³, Tuqyah Mohammad Althurwi⁴, Nasser Yahya Mohammed Dubayyi⁵, Amnah Abdouh Ahmad Arishi⁶, Mohammad Esmail Ali Zalzali⁷
SGLT2 Inhibitors Versus Intensive Low-Carbohydrate Dietary Programs for Glycemic Control and Early Detection of Renal Outcomes in Type 2 Diabetes
Background: Type 2 diabetes is highly prevalent and frequently complicated by chronic kidney disease. Sodium–glucose cotransporter-2 inhibitors (SGLT2i) and intensive low-carbohydrate dietary programs both improve glycaemia, but their comparative effects on early renal outcomes remain uncertain. Methods: A systematic search of PubMed and trial registries identified randomized and cohort studies in adults with type 2 diabetes evaluating SGLT2i or intensive low-carbohydrate programs versus usual care or higher-carbohydrate diets. Two reviewers independently screened records, extracted data, assessed risk of bias, and performed narrative synthesis. Results: Of 1,462 records, 9 studies (6 trials, 3 cohort/real-world; >19,000 participants) met inclusion criteria. Intensive low-carbohydrate programs produced larger short-term HbA1c reductions (−0.6 to −1.3 percentage points at 3–12 months) and 7–12 % weight loss, often allowing major de-intensification or discontinuation of insulin. SGLT2i yielded more modest but durable HbA1c reductions (−0.3 to −0.6 percentage points) and 2–4 kg weight loss with blood-pressure lowering. Across outcome trials and cohorts, SGLT2i reduced composite renal endpoints by about 30–40 % (hazard ratios =0.60–0.70; 95 % confidence intervals excluding 1.00), whereas low-carbohydrate interventions appeared renally neutral over 1–2 years. Conclusions: Both SGLT2i and intensive low-carbohydrate programs improved glycaemic control and cardiometabolic risk in adults with type 2 diabetes, but only SGLT2i showed robust renoprotective effects. These strategies may be complementary, and choice should consider renal risk, obesity, treatment goals, and capacity for sustained dietary change.
Sodium-glucose cotransporter 2 inhibitors,
Qassim Abdulatif Ahmad Algurairy¹, Hamad Mohammed Hamad Alhamad², Wasel Hassan Taher Alhashem³, Hussain Salman Alhassan⁴, Dalia Hassan Ibrahim Aljabr⁵, Ali Hussain Almeshqab⁶
Integrated Sepsis Detection Protocols Using Clinical Scores and Laboratory Triggers Versus Routine Assessment in Adult Emergency Patients
Background: Integrated sepsis detection protocols combining clinical scores with laboratory triggers are increasingly used in emergency departments, but their added value over routine assessment remains uncertain. Methods: A PubMed search identified studies comparing integrated sepsis detection protocols (clinical score plus laboratory trigger) with routine clinician assessment in adult emergency settings. Two reviewers selected studies, extracted data, and assessed risk of bias. Primary outcomes were time to antibiotics, intensive care unit (ICU) admission, and mortality; secondary outcomes were process measures and length of stay. Results: Fourteen studies (2 randomised or pragmatic trials, 12 cohort or beforeafter; >20,000 patients) were included. Integrated protocols consistently shortened time to first intravenous antibiotics, with median reductions of 2077 minutes versus usual care and 1-hour antibiotic compliance increase. Completion of bundle elements such as lactate measurement and initial fluid bolus improved, with gains of 2030 percentage points. Overall ICU admission rates were largely unchanged, although some studies reported more timely direct ICU transfer. Mortality effects were heterogeneous; several studies showed in-hospital mortality reductions of 411 percentage points, whereas others reported no significant difference. Conclusions: Across emergency care settings, integrated sepsis detection protocols improved timeliness and completeness of early sepsis management and may reduce mortality when linked to effective response pathways. These findings support local adaptation and implementation of integrated protocols as a component of sepsis quality-improvement initiatives in emergency departments.
Yousef Ali Fahed Alsalem¹, Yousef Hasan Taher Alhashem², Yousef Mohammad Al-Mohammad saleh³, Bader Ahmed Abdulmohsen Alshagageeg⁴, Ahmad Ali Mohammad Alalaiwi⁵, Abdullah Fahed Ahmed Alsalem⁶, Ali Abdullah Alshakhas⁷, Abdullah Saad Alqarni⁸
De-escalation Training to Reduce Workplace Violence in Emergency Nurses:A Systematic Review
Background: Workplace violence against emergency nurses is highly prevalent and threatens staff safety, morale, and retention. De De-escalation training is widely promoted as a core strategy to manage aggression, but its effectiveness in reducing violence and related harms in emergency departments remains uncertain. Methods: A systematic search of databases identified clinical trials and cohort studies evaluating de de-escalation or violenceviolence-prevention training for emergency nurses. Ten studies (randomised cluster trials, controlled cohorts, and pre pre-post designs) were included. Primary outcomes were workplace violence incidence and staff injuries; secondary outcomes were de de-escalation knowledge, confidence, attitudes, reporti ng behaviours, and psychological impacts. Risk of bias was assessed with design design-appropriate tools, and findings were synthesised narratively. Results: The 9 studies enrolled approximately 800 800-1,000 emergency nurses, with follow follow-up ranging from immediately postpost-training to 24 months. A large cluster trial reported a 52 % reduction in physical violence at 6 months (incident rate ratio 0.48; 95 % CI 0.29 0.29-0.80) and 63 % lower injury risk at 24 months (incident rate ratio 0.37; 95 % CI 0.17 0.17-0.83). A quasi quasi-exper imental study found workplace violence prevalence declined from 63.9 % to 46.2 % (18 % absolute risk reduction). Across studies, de de-escalation training consistently improved knowledge, confidence, and attitudes, but effects on incident rates were modest, h eterogeneous, and sometimes short short-lived. Conclusions: De -escalation training substantially enhanced emergency nurses’ competencies and perceived preparedness but only variably reduced workplace violence and injuries, with the most robust benefits observed when training was embedded in multifaceted organisational prevention programmes.
Dawood Salman Mohammed Aluthman, Fatima AbdMalik Mohd Aljuraidan, Zahrah Ahmed Hussin Alahmed, Hani Ali Abdullah Al-Hasan, Mariam Ali Mohammed Al-Fajri, Majid Abdullah Alwosaibai, Adraa Ibrahim Alshoreet, Nawal Abdul-Wahab Alibrahim
Artificial Intelligence Support For Digital Breast Tomosynthesis And 2DMammography: A Systematic Review Of Diagnostic Accuracy
Background: Artificial intelligence support for digital breast tomosynthesis and two dimensional mammography is increasingly integrated into breast cancer screening, yet the overall diagnostic accuracy and impact on workflow across clinical settings remain uncertain. Methods: A systematic search of PubMed from inception to May 2024 identified clinical trials and cohort studies evaluating artificial intelligence systems used as standalone readers or as decision support for radiologists in digital mammography or digital breast tomosynthesis. Studies were eligible if they reported diagnostic accuracy outcomes such as sensitivity, specificity, area under the receiver operating characteristic curve, cancer detection rate, or recall rate. Two reviewers performed screening, data extraction, and risk of bias assessment using a standardised tool, with narrative synthesis only. Results: Nine studies, including more than 560,000 mammographic examinations, met the inclusion criteria. Standalone artificial intelligence achieved area under the curve values around 0.84 to 0.94 and was non inferior to average radiologists in several datasets. Concurrent artificial intelligence support increased reader area under the curve by about 0.02 to 0.06, raised sensitivity by approximately 3 to 10 percentage points, and reduced reading time by 20 to 50 percent. In large screening cohorts, cancer detection rates increased by about 14 to 18 percent, while recall rates were either stable or modestly reduced and positive predictive value improved by roughly 3 to 5 percent. Conclusions: Artificial intelligence support for digital mammography and digital breast tomosynthesis shows consistent gains in diagnostic accuracy and efficiency, although effect sizes vary by modality, integration strategy, and case mix, and long term clinical outcomes still require confirmation.
Breast Neoplasms, Mammography, Tomography X-Ray Computed, Artificial Intelligence, Mass Screening, Computer-Assisted Diagnosis.
Hamad Salem Al Yami ¹, Hawraa Hejji Saleh Aljumaiah ², Huda Ridha Alessa ³, Maryem Abdullah Al Alosayif ⁴, Rabab Mansour Al Hashem ⁵, Bashayr Mohammed Musawwid Asiri ⁶
Comparative Effectiveness of Video and Direct Laryngoscopy on First-Pass Success andPeri-intubation Events
Background: First-pass success during tracheal intubation is critical for reducing peri-intubation complications, especially in emergency and critical care settings. Video laryngoscopy may offer advantages over direct laryngoscopy in improving glottic visualization and intubation outcomes. Methods This systematic review included studies comparing video and direct laryngoscopy in adult patients undergoing tracheal intubation in operating rooms, emergency departments, or intensive care units. A comprehensive PubMed search (inception-July 2025) identified randomized clinical trials and cohort studies reporting first-pass success and related outcomes. Results Eight studies (five randomized trials, three cohorts; n = 8,700) met inclusion criteria. First-pass success rates ranged from 61.9% to 98.3% for video laryngoscopy and 59% to 96.2% for direct laryngoscopy. Four studies reported significantly higher success with video (e.g., 85.1% vs 70.8%; risk difference 14.3%, 95% CI 9.9-18.7). Two studies showed no difference, and one favored direct laryngoscopy in a prehospital setting. Video laryngoscopy reduced esophageal intubation (RR 0.44, 95% CI 0.24-0.80) and aspiration risk (RR 0.63, 95% CI 0.41-0.96), with similar rates of hypoxemia and hypotension. Time to intubation was marginally longer with video but not clinically significant. Conclusions Video laryngoscopy improves first-pass success and reduces airway-related complications compared to direct laryngoscopy in most adult emergency and perioperative intubations. Operator training and setting influence effectiveness.
Video laryngoscopy, direct laryngoscopy, airway management, tracheal intubation, first-pass success, critical care.
Anas Ismail Alkhdour¹, Anas Yahia Abdo Alasmari², Abdullah Saad Alshahrani³, Walled Abdullah AlSufyani⁴, Saleh Ghazia Falah Alharbi⁵, Abdulrahman Mohammed Alasmari⁶, Ahmed Mohammed Hadadi⁷, Sultan Khaled Alhussaini⁸
Comparing Devices and Training for Needlestick-Injury Prevention: A SystematicReview
Background: Needlestick injuries are frequent among nurses and dental assistants and carry substantial risk of blood borne infection. Safety engineered devices and education programmes are both promoted for prevention, yet their comparative effectiveness and feasibility for these staff groups remain uncertain. Methods: Studies that evaluated safety engineered needle devices, education or combined interventions to reduce needle related injuries in nurses or dental assistants were identified through PubMed and supplementary databases from inception to August 2025. Clinical trials, quasi experimental studies and cohort designs reporting injury incidence or rates were eligible. Thirteen studies met inclusion criteria, of which ten were clinical trials or cohort studies. Risk of bias was appraised with design appropriate tools, and findings were synthesised narratively. Results: Safety engineered devices consistently reduced injury rates, typically by 40-60 percent relative to conventional needles, for example from 3.39 to 1.50 injuries per 100 full time equivalent staff, or with relative risks around 0.3-0.6. Education alone improved knowledge and reported safe practices but produced smaller and sometimes transient reductions, for example self-reported injury prevalence falling from 40 percent to 15 percent over 3-6 months. Interventions that combined devices and training achieved the largest effects, with odds ratios around 0.3 compared with usual practice. Heterogeneity in design, outcome definition and follow up limited formal pooling. Conclusions: Evidence indicated that passive safety engineered devices substantially reduced needle related injuries, and that combining such devices with structured training offered the greatest protection for nurses and dental assistants. Education alone was beneficial but less effective and required repetition to sustain impact.
Needlestick Injuries, Safety Devices, Education, Nursing, Dental Assistants, Occupational Exposure.
Halima Salman A. Karim Alenaki¹, Safa Habib Alhubail², Azhar Ali Al Omani³, Wejdan Mohammed Al Barrak⁴, Eman Abdullah Yusef Al Abbas⁵, Sakina Yagoub Yousef Al Sulais⁶
Care Pathways Combining Anesthesia Practices and Nursing Interventions forPostoperative Delirium Prevention
Background: Postoperative delirium (POD) is a frequent, harmful complication after surgery. Multicomponent pathways that coordinate anesthesia practices with nurse-led prevention strategies are increasingly adopted, yet their effectiveness across surgical settings remains variably reported. Methods: A systematic search of PubMed (to July 2025) identified studies evaluating integrated anesthesia-nursing pathways for POD prevention in adult inpatients. Randomized and observational designs were eligible. Primary outcome was POD incidence (validated tools); secondary outcomes included delirium duration, length of stay, pain, sleep quality, and early recovery. Results: Thirteen studies met criteria (9 randomized trials and 4 cohorts). Multicomponent pathways frequently reduced POD versus usual care, especially in higher-risk populations. Examples included an antiinflammatory drug bundle in hip-fracture surgery (15% vs 44%; RR =0.33) and esketamine plus dexmedetomidine in thoracic surgery (14.6% vs 30.9%; RR=0.47). A large implementation cohort reported a month-over-month decline in delirium after bundle rollout (adjusted odds ratio 0.96; 95% confidence interval 0.94-0.97). Secondary outcomes generally favored intervention groups, including shorter hospitalization, improved sleep, lower pain, and higher early recovery scores. Conclusions: Integrated perioperative pathways that combine anesthesia optimization with nurse-led nonpharmacologic measures were associated with lower delirium and better recovery metrics, whereas single-component changes often showed limited effect. Adoption should emphasize multicomponent design, staff training, and implementation fidelity, with pragmatic trials to standardize effective elements across surgical contexts.
Postoperative delirium, perioperative care, anesthesiology, nursing, care bundles, enhanced recovery, outcomes
Wasayf Salah Al Muraysel ¹, Mohammed Abdullah Al Khalifah 2, Latifa Mohammed Bubshait 3, Meshari Mohammed Algarzai 4, Turki Abdullah Alzahrani 5, Naifah Abdullah Al Amiri 6, Nabiha Yousf Almudhwi 7, Laila Ibrahim Alsaihati 8
Digital Morphology for Peripheral Blood Smears in Leukemia Detection:A Systematic Review
Background: Peripheral blood smear examination is foundational for leukemia detection, yet manual review is laborintensive and variable. Digital morphology and artificial intelligence (AI) systems promise faster triage and standardized classification. This review synthesized diagnostic accuracy for detecting leukemia on peripheral smears. Methods: PubMed was searched from inception to April 2025. Eligible studies were observational diagnosticaccuracy cohorts evaluating digital morphology or AI on peripheral blood smear images against manual microscopy or integrated clinical diagnosis. The primary outcome was sensitivity/specificity; secondary outcomes included predictive values, agreement, and time to result. Results: Of 1,245 records, 245 duplicates were removed and 1,000 titles/abstracts were screened; 80 full texts were reviewed and 10 cohorts were included. Digital analyzers showed high specificity for common leukocytes (often >90-95%); blast sensitivity varied by platform and case-mix. A compact analyzer reported specificity >94% with blast sensitivity 21-86%. Another platform achieved blast sensitivity 98.4% and specificity 64.0%. AI-assisted APL screening yielded sensitivity 95.8% and specificity 100.0%. Image-classification studies reported sensitivity 97.86% and specificity 100.0% on held-out tests, with APL recall 97.4%. Post-verification correlations for abnormal differentials exceeded 0.93, and PPV/NPV were frequently ≥95%. Conclusions: Digital morphology and AI reliably triaged peripheral smears with high specificity and context-dependent blast sensitivity. They are best deployed as screening tools with mandatory expert confirmation, supported by local validation and external prospective AI verification.
Shafi Fiyadh Kasb Alshammari¹, Salem Mousa Ahmed Alzahrani², Afnan Abdullah Dhafer Alshehri³, Ramadan Juma’an Ramadan Alzahrani⁴, Abdullah Ahmed Abdullah Alzahrani⁵
Acquired Methemoglobinemia from Local Anesthetics Used for Airways:Incidence, Risk Factors, and Management
Background: Acquired methemoglobinemia from topical/local anesthetics used for airway procedures is uncommon but clinically important. Risk appears highest with benzocaine sprays during transesophageal echocardiography (TEE) or bronchoscopy, whereas standard-dose lidocaine typically yields only minor, asymptomatic methemoglobin (MetHb) changes. Methods: We systematically searched PubMed (to June 2025), screened records in duplicate, and included observational clinical trials or cohort/case-control studies evaluating airway topical/local anesthetics and methemoglobinemia. Data were extracted in duplicate and synthesized narratively without meta-analysis due to heterogeneity in designs, exposures, and outcome definitions. Results: Nine observational studies met eligibility (0 randomized trials). Across mixed procedure cohorts, incidence was low (0.035% overall; 33/94,694 procedures), with higher procedure-specific rates for TEE (0.250%) and bronchoscopy (0.160). A large TEE program reported benzocaine-associated incidence 0.067% (95% CI 0.040-0.100). Inpatient status markedly increased risk (13.7 vs 0.14 per 10,000 for inpatients vs outpatients). Prospective studies of lidocaine topicalization/infiltration showed trivial mean MetHb shifts (e.g., =0.5% to 0.6%) without clinical toxicity. Conclusions: Airway topical/local anesthetic-associated methemoglobinemia is rare and concentrated around benzocaine spray in medically complex inpatients. Routine lidocaine use at standard doses demonstrated minimal clinical risk. Early recognition with co-oximetry and timely methylene blue remain central to excellent outcomes, and risk can be minimized through agent selection and dosing discipline.
Methemoglobinemia, Airway management, Anesthetics local, Benzocaine, Lidocaine, Transesophageal echocardiography
Maher Ahmed Hamad Al Sultan¹, Shaker Ahmed Abdullah Al Faraj², Omar Adel Omar Alsubaie³, Abdullah Shafi Rajeh Alshehri⁴, Bayan Mansour Hamad Almansour⁵ Bashayer Sulaiman Rubayyi Alshammari⁶, Norah Adel Abdulaziz Al Jaber⁷, Zahra Ali Alhazza⁸
Digital-Era Nurse Leadership and Psychological Empowerment DuringeHealth Implementation: A Systematic Review
Background: Hospitals continue to scale telehealth and electronic health records (EHRs), placing nurse leadership and psychological empowerment at the center of successful implementation. Leadership that protects learning time, ensures responsive support, and involves nurses in redesign is theorized to improve adoption and retention. Methods: A systematic search (PubMed) from inception to May 2025 identified studies of hospital-based nurses examining leadership constructs and psychological empowerment during telehealth/EHR implementation. Eligibility required quantitative or mixed-methods designs reporting adoption or retention (intent-to-stay/leave) and empowerment measures. Two reviewers screened, extracted, and synthesized data narratively in line with PRISMA. Results: Nine observational studies (cross-sectional or cohort) were included. Adoption-related findings showed that leadership and empowerment-adjacent factors (competence, autonomy, self-efficacy) were associated with higher readiness and use. Examples included EHR readiness 52.8% (95% CI 47.9-56.6) with higher odds among staff with positive attitudes and technology self-efficacy; comprehensive EHRs were associated with fewer fair/poor quality ratings (OR 0.83; 95% CI 0.71-0.96). Implementation leadership independently predicted nurses’ actual use of mobile health at the point of care (β 0.22; p=0.001). Conclusions: Across diverse hospital settings, digitally competent, supportive leadership that fosters psychological empowerment aligned with higher eHealth adoption and more favorable retention signals. Implementation programs should integrate leadership development, co-design, usability remediation, and protected learning time.
Farah Abdulaziz Al-Abdrabalnabi¹, Abrar Hassan Al-Abdulaal², Asadiah Hassan Al-Ghazwi ³, Rabab Jaber Al- Hammad⁴, Fatimah Jaber Al-Hammad⁵, Zainab Ali Alrubeh⁶, Noor Jamal Alzayer⁷, Mortadh Jaffar Ali Al-Salem⁸, Sawsan Shareedah Al-Turaiky⁹
Impact of Patient-Assisted Compression and Pressure-Guided Paddles onMammography/DBT Performance
Background: Breast compression optimizes image quality and dose in mammography and digital breast tomosynthesis (DBT), yet pain can deter re-attendance. Patient-assisted compression (PAC) and pressureguided paddles aim to improve tolerability while preserving technical performance. Methods: A PRISMA-conformant PubMed search (inception-31 March 2025) identified English-language human studies comparing PAC or pressure-/shape-guided paddles with technologist-controlled compression. Two reviewers screened/extracted data with calibration (κ=0.84) and used Joanna Briggs Institute tools for risk of bias. No meta-analysis was undertaken. Results: Of 1,063 records (92 duplicates removed), 971 titles/abstracts were screened and 102 full texts assessed; 12 studies were included (3 randomized trials, 9 cohorts; sample sizes 39-25,286). The primary outcome, pain (0-10 scale), was modestly reduced: a multicentre trial of curved paddles showed a mean difference -0.19 (95% CI -0.28 to -0.09); a PAC randomized study reported lower discomfort (P=0.014). A DBT cohort reported mean pain 1.9/10 with 19.3% moderate/severe. Pressure-guided flexible paddles standardized compression, lowering thickness (-3.74 mm craniocaudal; -6.70 mm mediolateral oblique), reducing pressure variability (-55% and -34%), and decreasing average glandular dose (AGD) (-0.13 mGy MLO); 87% would recommend. Implementation studies reduced mean pressure (17.1to12.8 kPa) and “over-compressed” views (26% to 2%). Conclusions: PAC and pressure-guided paddles provided small but consistent gains in patient experience and compression standardization without systematic loss of image quality or dose performance. Implementation should prioritize pressure targets (8-14 kPa), structured PAC coaching, and monitoring of positioning, recalls, dose, and re-attendance.
mammography, digital breast tomosynthesis, breast compression, patient-assisted compression, pressure-guided paddles, average glandular dose
Samar Abdulhameid Alfraij¹, Mazen Alghamdi², Sahar Nasser Albishi³, Ashwag Nasser Othman Albishi⁴ Fatima Obaid Jaber Albishi⁵, Abdulaziz Sulaiman Abdulaziz Al Oraini⁶, Aishah Nasser Almubayyedh⁷
Emergency Medical Services Use of Capillary Ketone Meters for SuspectedDiabetic Ketoacidosis: A Systematic Review
Background: Diabetic ketoacidosis is a time-critical emergency; emergency medical services (EMS) may benefit from capillary β-hydroxybutyrate testing to improve recognition and trigger early care pathways. Methods: PubMed, Scopus, citation lists, and trial registries were searched from inception to 30 September 2024 for clinical trials and cohort studies evaluating EMS-performed capillary ketone measurement in suspected diabetic ketoacidosis. Dual screening, duplicate data extraction, and designappropriate risk-of-bias tools (QUADAS-2/JBI) were used. A narrative synthesis was conducted without meta-analysis. Results: Of 263 records identified, 71 duplicates were removed; 192 titles/abstracts were screened, 29 full texts were assessed, and 1 stepped-wedge feasibility cohort was included. The multicentre United Kingdom study enrolled 388 EMS encounters (control 203; intervention 185) and implemented a “highrisk DKA” bundle triggered by capillary β-hydroxybutyrate ≥3.0 mmol/L. Recognition of suspected highrisk diabetic ketoacidosis increased from 2.5% (5/203) to 6.5% (12/185), a +4.0 percentage-point difference. Among hospital-diagnosed cases, prehospital crystalloid initiation rose from 33.3% (3/9) to 45.5% (5/11). Hospital pre-alerting increased qualitatively, while scene-time effects were not reported. No device-related serious adverse events were described; paramedic and emergency-department staff reported the approach as feasible and acceptable. Large contextual cohorts without prehospital ketone testing were excluded but highlighted the implementation gap. Conclusions: EMS capillary ketone testing appeared feasible and was associated with improved early recognition and pre-arrival actions, though evidence was limited to a single underpowered feasibility cohort. Protocolized implementation with audit is reasonable, and multicentre effectiveness studies reporting patient-centred outcomes are needed.
Emergency Medical Services, Diabetic Ketoacidosis, β-Hydroxybutyrate, Point-of-Care Testing, Prehospital Care, Diagnostic Pathways
Saleh Abdullah Ali Al Dighrir¹, Mujahid Dhafir Saleh Alyami², Amer Saleh Ali Almahri Alyami³, Abdulaziz Ahmed Bin Marshad Alyami⁴, Faris Mahdi Salem Aldighrir⁵, Mansour Saleh Hussein Almahri⁶, Amer Mohammed Alkhurim⁷
Same-Day Screening of Diabetic Complications in Outpatient Clinics: ASystematic Review
Background: Fragmented, multi-visit screening for diabetic retinopathy, kidney disease, and neuropathy in routine care leads to missed tests and delayed referral. Same-day, multi-component screening in outpatient clinics is proposed to improve completion and diagnostic yield. Methods: A PRISMA-guided review searched PubMed from inception to September 2024 (Humans, English). Eligible designs were clinical trials or cohorts evaluating same-day screening bundles assessing ≥2 complication domains (retina, kidney, foot/neuropathy) within one outpatient encounter, versus usual care or pre-implementation periods. Primary outcome was completion of all eligible screens during the visit; secondary outcomes included detection yield, referral/process measures, patient experience, and safety. Results: Ten studies (all observational cohorts; 5 before-after, 3 prospective, 2 quasi-experimental) met criteria, from the UK, Europe, North America, and the Middle East. Sample sizes ranged 236-4,022. Integration models most commonly combined non-mydriatic retinal imaging with foot/neuropathy testing and urine albumin-to-creatinine ratio. Across studies, same-day programs increased multi-domain completion versus prior workflows (reported directionally in 6/10). Detection yields at the index visit were substantial: moderate/high-risk foot 56.6%, new painful neuropathy 25%, peripheral artery disease 19-26%, and sensory neuropathy 3-31%, while retinal imaging identified previously unrecognized diabetic retinopathy in routine primary-care pathways. Conclusions: Same-day, bundled screening in outpatient clinics was feasible and acceptable, with consistent gains in completion and meaningful same-visit detection of microvascular complications. Health systems should pilot co-located models with standardized referral protocols and measure completion, yield per 100 screened, time-to-referral, and costs.
Diabetes mellitus, Diabetic retinopathy, Diabetic neuropathies, Albuminuria, Point -of-care systems, Primary health care
Mohsen Hassan Alwalan¹, Hamad Masoud Alyami², Mansour Saeed Althaibah³, Hadi Ali Mana⁴, Mohamed Hadi Almunyif⁵, Rashed Saleh Saud Almurdif⁶, Rawan Ezzi Abufaia⁷
Skin and Allergic Conditions Linked to Personal Protective Equipment inHealthcare Workers: Burden, Prevention, and Care
Background: Personal protective equipment is essential in healthcare, yet sustained use can provoke irritant and allergic skin conditions that impair comfort, adherence, and work ability. A synthesis focused on burden, prevention, and care is needed to guide procurement and practice. Methods: A protocol driven search of PubMed identified studies from inception to March 2025. Eligible designs were clinical trials and cohort studies that evaluated healthcare workers using gloves, masks, respirators, goggles, or face shields, and reported dermatologic outcomes with explicit definitions. Screening and extraction were performed in duplicate, risk of bias was appraised by design specific tools. No metaanalysis was performed. Results: Fourteen studies met criteria, seven cohorts and three trials, sample sizes ranged from 17 to 2,053, follow up ranged from 3 days to 10 years. In a hospital cohort, hand rub applied on wet skin increased hand eczema risk, odds ratio 1.78, 95 percent confidence interval 1.11 to 2.87. Apprentice cohorts reported new onset eczema with frequent washing, odds ratio 1.5, 90 percent confidence interval 1.0 to 2.3. Longitudinal glove programs still detected latex sensitization at 1.0 per 1,000 person years and allergic contact dermatitis at 2.50 per 1,000 person years. Consecutive respirator wear increased facial transepidermal water loss and corneocyte fragility over three shifts, consistent with early barrier injury. A cluster trial showed greater reduction in Hand Eczema Severity Index with a structured skincare program versus control, while a randomized cross over trial suggested fewer facial reactions with skin protectants under respirators, fit preserved under monitored conditions. Conclusions: Evidence supported modifiable risks, avoid hand rub on wet skin, reduce accelerator and latex exposure, optimize respirator fit and relief schedules, implement moisturization programs compatible with infection prevention.
Personal Protective Equipment, Healthcare Personnel, Dermatitis, Contact Dermatitis, Latex Hypersensitivity, Respiratory Protective Devices
Fatema Abdulaziz Alsaleh¹, Sukinah Ali Alshowikhat², Layla Mousa Al Bashrowi³, Riham Nader Alghurab⁴, Alia Mahdi Almaidani⁵, Maryam Saeed Bawadi⁶, Mezharah Mohammed B. Al Makhalas⁷, Bushra Mohamed Alhamadi⁸
Vasopressor Strategy for Neuraxial Related Hypotension During CrashCesarean
Background: Crash cesarean requires rapid, reliable hemodynamic control. Neuraxial anesthesia frequently precipitates hypotension, therefore optimized vasopressor strategies are central to maternal safety and fetal perfusion. Methods: We conducted a systematic search of PubMed from inception to April 2024. Eligible studies were clinical trials or cohorts evaluating vasopressors for prevention or treatment of neuraxial related hypotension during crash or urgent cesarean. Two reviewers screened records, assessed risk of bias with appropriate tools, and extracted data in duplicate. The primary outcome was the incidence of maternal hypotension. Secondary outcomes were maternal bradycardia, nausea or vomiting, rescue vasopressor use, and neonatal Apgar scores and umbilical arterial pH. No meta-analysis was performed. Results: The search identified 547 records, 72 duplicates were removed, 475 titles and abstracts were screened, 45 full texts were assessed, and 10 studies were included (total n = 1150). Prophylactic infusions reduced hypotension compared with reactive bolus strategies, with absolute risk differences commonly between 30 and 70 percentage points across trials, for example 20% vs 90%, 31–37% vs 67%, and 15.5% vs 71.1. When active agents were compared, norepinephrine and phenylephrine maintained blood pressure similarly, while norepinephrine reduced maternal bradycardia relative to phenylephrine. Ephedrine was associated with more maternal nausea or vomiting, for example 22.2% vs 4.4% with phenylephrine. Neonatal outcomes, including umbilical arterial pH and Apgar scores, did not differ meaningfully across agents. Conclusions: In crash or urgent cesarean under neuraxial anesthesia, protocolized vasopressor infusions provided superior prevention of hypotension compared with bolus only approaches. Agent selection may be individualized, with phenylephrine or norepinephrine as first line and ephedrine reserved for selected physiologic profiles.
Cesarean section, Spinal anesthesia, Hypotension, Vasoconstrictor agents, Phenylephrine, Norepinephrine
Shahad Abdulrahman Alawjan¹; Dalal Bader Almudehem²; Ayed Mulfi Ayed Almajdi³; Maram Eid Alharbi⁴; Nourah Hassan Alamri⁵; Sarah Bader Alanazi⁶; Hamad Salem Hamad Al Alshahi⁷; Amjad Awad Rahan Alyami⁸
Pharmacogenomic Guided Pain Management in Surgery: Patient PainOutcomes
Background: Postoperative pain remains common and variable across patients; pharmacogenomic guidance seeks to tailor analgesics to genotype to improve pain control and reduce opioid exposure. Methods: A systematic search of PubMed from inception to 28 Feb 2025 identified randomized and cohort studies in surgical populations where genotyping informed analgesic selection or dosing. The primary outcome was postoperative pain intensity within 24 to 72 hours on validated scales; secondary outcomes included opioid consumption converted to oral morphine equivalents, adverse events, and early recovery. Screening, extraction, and risk appraisal were performed in duplicate; findings were narratively synthesized. Results: Ten studies were included, four randomized trials and six cohorts. Pain effects were mixed. One arthroplasty trial reported lower mean pain over 10 days with genotype guidance, 3.1 vs 4.2 on a 0 to 10 scale, p<0.05, while a knee arthroplasty trial showed no difference at 24 hours, Overall Benefit of Analgesia Score 4.2 vs 4.7, p=0.55. A cohort within an enhanced recovery pathway showed better composite analgesia on postoperative day 1, 3.8 vs 5.4, and roughly 50% lower opioid use, p<0.01. Another randomized study observed lower two week opioid totals, median 200 vs 230 mg, p=0.047, with similar pain. In pediatric adeno- tonsillectomy, a COMT haplotype increased odds of opioid intervention, odds ratio 2.6, 95% confidence interval 1.2 to 5.4. Where reported, adverse effects were fewer with genotype guidance. Conclusions: Across surgical settings, genotype guided prescribing tended to reduce opioid consumption without worsening pain; effects on pain intensity were uncertain. Benefits appeared greatest when actionable phenotypes were targeted and recommendations were implemented reliably.
Pharmacogenetics, Pharmacogenomics, Postoperative pain, Analgesics, Perioperative care, Genotype
Lyale Ali Abdullah Jalood¹; Lamia Saleh Aldossary²; Ola Saad Almutairi³; Eman Mohammed Busaleh⁴; Hawra Hassan Olaiwat⁵; Atiaf Faisal Alkhleef⁶; Rihanah Hassan Almahdi⁷; Naemah Rashed Bin Reshedan⁸
Influence of Abutment Retention Method on Dental Implant Prosthesis: Implant Stability and Screw Loosening
Background: Retention method for implant implant-supported crowns, screw retained or cement retained, may influence prosthesis stability and the risk of screw loosening, while implant survival typically remains high. Clarifying comparative mechanical outcomes can guide prosthodontic planning and maintenance. Methods: A systematic search of PubMed identified clinical trials and cohort studies from inception to 28 Feb 2025 comparing cement cement-retained with screw screw-retained restorations. Eligibility required human in in-vivo data reporting implant stability and screw loosening. Two reviewers screened, extracted data in duplicate, and assessed study quality. No meta meta-analysis was performed; results were synthesised narratively. Results: Ten studies met criteria followfollow-up 2–10 years). Implant survival was high and similar between groups across studies, typically 93–100 percent. Marginal bone changes were small and comparable; one 10-year comparison reported mean bone loss ~1.1 mm for both retention types. Screw loosening occurred more often in screw screw-retained restorations. A cohort reported loosening in 32 percent of screw screw-retained partial prostheses versus 9 per cent of cement cement-retained. A randomised posterior single single-crown trial observed 1 of 28 screw screw-retained crowns loosening (3.6 percent) versus 0 of 28 cement cement-retained at 24 months. External quantitative syntheses within the included evidence indicated lower rete ntionntion-failure risk for cement cement-retained designs (risk ratio 0.26; 95% CI 0.09 0.09–0.74 short term; pooled ~0.31 at ≥5 years). Secondary findings noted rare decementation with modern adhesive protocols and context context-dependent biological complications when excess c ement was not controlled. Conclusions: Choice of retention did not affect implant survival or bone stability; it chiefly altered the complication profile. Cement retention reduced screw loosening, whereas screw retention avoided cement cement-related biological risks; case case-specific selection remains essential.
Keywords: Dental implants, Dental abutments, Screw loosening, Cementation, Prosthesis retention, Treatment outcome
Tamer Aljamaan¹; Ahmed Abdulrahman Almuashi²; Noura Adel Aldhamer³; Nourah Yahya Alkhaldi⁴; Maryam Abdullah Abdullah Alhmood⁵; Zakariya Ibrahim Ahmad Alsadah⁶
Nurse-Led Ultrasound at Point of Care (POCUS) in Emergency and Critical Care: Accuracy and Outcomes
Background: Nurse-led point of care ultrasound (POCUS) is increasingly used in emergency and critical care where rapid bedside diagnostics and procedural support are essential. Its accuracy and clinical impact across settings remain underexplored. Methods: We systematically searched PubMed and Scopus from inception to 28 February 2025 for clinical trials and cohort studies evaluating nurse-performed POCUS in adult and pediatric emergency or intensive care. Eligible outcomes included diagnostic accuracy, vascular or procedural success, and patient-centered metrics. Data were extracted in duplicate and synthesized narratively according to PRISMA guidelines. Results: Eleven studies (3 randomized trials, 8 cohorts) enrolling 50–302 participants each were included. Nurse FAST for trauma achieved sensitivity 84.4% (95% CI 72.1–92.2) and specificity 98.4% (94.9–99.6). Nurse lung ultrasound in dyspnea showed sensitivity 95.3% (92.6–98.1) and specificity 88.2% (84.0–92.4). For vascular access, ultrasound guidance increased first-attempt success (odds ratio 2.52; 95% CI 1.09–5.92). In arterial puncture, ultrasound reduced procedure time and complications compared with palpation. Management changes were reported in 26–84% of cases, particularly in fluid resuscitation and respiratory care. No study demonstrated mortality benefits, but adverse events were rare. Conclusions: Nurse-led POCUS demonstrated strong diagnostic accuracy, improved procedural success, and frequently informed management decisions across emergency and critical care. Wider adoption requires standardized training, competency assessment, and larger multi-center evaluations to determine patient-level outcomes.
Point-of-care ultrasound, nursing, Emergency medicine, Intensive care units, Diagnostic accuracy, Vascular access.
Mohammed Ahmed Aljurayyad¹, Areej Ibrahim Alarani², Hassan Ali Al-Abdulghani³, Ashraf Ali Al Turaik⁴, Weam Amin Alramadhan⁵, Habib Ali Alkhwailidi⁶, Amal Salman Alawami⁷, Sukynah Muhammed Alabdullah⁸